Disruption Through Complements

Allosteric inhibition through core disruption.

Although inhibitors typically bind pre-formed sites on proteins, it is theoretically possible to inhibit by disrupting the folded structure of a protein or, in the limit, to bind preferentially to the unfolded state. Equilibria defining how such molecules act are well understood, but structural models for such binding are unknown. Two novel inhibitors of beta-lactamase were found to destabilize...

When conversation is not enough: assessing infinitival complements through elicitation.

Children with language impairment have been found to show limited usage of infinitival complements, one of the earliest complex sentence types to emerge and a significant form in school-age language. Children's production of infinitival complements in conversation is not sufficient to tell us what they know about this form. This article describes a story completion procedure for eliciting infin...

Complements ?

This paper revises the interdependence between flexible technology and product innovation in the context of a monopolistic firm. Previous literature argued that flexible machinery reduces the cost of incremental innovation. To take interactions beyond the fixed cost into account, we introduce a 2-period optimization model where technology, innovation and price are chosen first, then stochastic ...

Urban Creativity through Displacement and Spatial Disruption

Predicate Complements

This paper briefly presents the canonical HPSG treatment of predicate complements (Section 1) and points out a number of problems with it (Section 2). Then it presents an alternative (Section 3) and shows how it avoids or solves the problems with the canonical treatment (Section 4). 1 The raising treatment of the predicate complements In mainstream HPSG predicate complements are treated along t...